Keto diet: New study unearths sex differences

A recent study investigates how the keto diet affects male and female mice. The researchers find that in females, the diet’s benefits are absent.

Experts originally designed the ketogenic diet, which people often refer to as the keto diet, as a treatment for epilepsy. The keto diet allows a liberal consumption of fats and an adequate amount of protein but heavily reduces the intake of carbohydrates, such as starch, sugar, and fiber. Usually, the body burns carbohydrates as its primary source of energy. However, if there are none available, it switches to burning stored fats.

Keto sex differences

Although there is evidence that the keto diet might offer some benefits for certain people, there is much debate surrounding this diet and its long-term effects.

A recent study brings into question whether the keto diet provides the same benefits for females as it does for males. A new study using mouse models focused on sex differences in relation to the keto diet.

“Most studies of the ketogenic diet for weight loss have taken place in small numbers of patients or in only male mice, so sex-based differences in response to this diet are unclear.”

To investigate, Dr. Abel and research assistant Jesse Cochran fed male and female mice either a ketogenic diet or a standard diet. The keto diet comprised 75 percent fat, 3 percent carbohydrates, and 8 percent protein by mass, while the control diet consisted of 7 percent fat, 47 percent carbohydrates, and 19 percent protein.

After 15 weeks, the researchers found that the male mice on the keto diet maintained blood glucose control and lost body weight. The female mice, however, gained weight.

These female mice also had poorer blood sugar control compared with the female mice that ate a standard diet. According to the authors, “[they] developed impaired glucose tolerance.”However, the researchers make it clear that it is important to speak with a doctor before embarking on the keto diet. This study is one of very few to investigate potential sex differences in the effectiveness of the keto diet. However, the study used an animal model, so scientists will still need to carry out investigations in humans before we can reach any solid conclusions.